By: IPP Bureau
Last updated : November 14, 2025 8:36 pm
Hyaluronic acid is among the world's most valuable biopolymers, with applications spanning from dermal fillers and wound healing to drug delivery and tissue engineering
In a major milestone for sustainable biomanufacturing, synthetic biology company Enzymit, in partnership with agricultural cooperative Cosun, has successfully produced multi-kilogram quantities of high-purity hyaluronic acid (HA) at pilot scale using an innovative enzyme-only, cell-free process.
The 200-liter campaign demonstrated unprecedented efficiency, consistency, and control over HA molecular size, signaling a potential revolution in the $9.4 billion global HA market.
"This isn't just a breakthrough in hyaluronic acid production - it's a glimpse into the future of how we make molecules," said Gideon Lapidoth, CEO of Enzymit.
"By combining AI-designed enzymes with a robust cell-free system, we've removed biological bottlenecks and proven that precision manufacturing of biomolecules is no longer limited by what cells can or can't do."
Hyaluronic acid is among the world's most valuable biopolymers, with applications spanning from dermal fillers and wound healing to drug delivery and tissue engineering. The global hyaluronic acid products market valued at $9.43B in 2025 is projected to grow to $15.94B by 2035, underscoring the urgent need for high-purity, high-performance biomaterials.
Enzymit's cell-free process is the first to let manufacturers set the size of hyaluronic acid during production. Using the same enzymatic process, it can make HA in defined sizes from about 10 kDa to about 4 MDa with a very narrow size distribution, adjusted through standard production settings rather than changing enzymes or organisms.
"We are honored to have been a part of Enzymit's journey in scaling their lab protocol to pilot scale, and very proud that process development and first-ever factory operation were successful based on our existing manufacturing assets. It's exciting to see this cell-free technology become an industrial reality within such a short amount of time," said Marie Dobenesque, Chief Technology Officer, Cosun RD&I.