C2i Genomics Partners with Twist Bioscience for cancer detection

Twist will leverage C2i’s leadership in whole-genome cancer signatures across solid cancers to generate unique synthetic reference materials for cancer detection validation in labs across the globe

C2i Genomics, a cancer intelligence company, and Twist Bioscience Corporation, a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, announced a partnership to develop whole-genome cancer reference materials. This resource will provide diagnostic labs around the globe with the ability to better validate and monitor the quality of their whole-genome cancer screening and minimal residual disease (MRD) products. In addition, C2i will integrate Twist’s library preparation into their MRD workflow.

Today in cancer diagnostics, a major obstacle facing diagnostic labs and regulators is the lack of standardized reference samples for labs to use for the analytical validation of their whole-genome assays. Especially in the complex field of oncology, there is a heightened need for advanced technology to help execute better treatment decisions, and ultimately, to save more lives.

Under the collaboration, C2i will use its artificial intelligence (AI) to identify a very large set of variants across the entire genome known to be associated with cancer signatures. Twist will then synthesize each of these variants, tuning them up or down to allow for similarity to natural samples, to create a whole-genome sequencing-focused set of reference materials. The reference standard kits will be available through Twist Bioscience.

“There is a tremendous need to have a consistent reference standard for the detection of cancer and minimal residual disease,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “We expect that the development of this exceptionally robust set of reference standards for whole-genome sequencing will complement our cfDNA Pan-Cancer Reference Standards, which can be used in liquid biopsy assays. We believe both of these products will enable our customers to create innovative solutions that accurately detect cancer initially and upon recurrence. C2i’s approach through AI and WGS has the potential to truly change the treatment paradigm.”

 “C2i is committed to increasing the accessibility of whole-genome cancer detection and monitoring to support researchers and clinicians in improving oncology care for patients. We’re proud to work closely with Twist, as these new reference kits will solve an urgent unmet need for lab validation and proficiency testing materials in the cancer diagnosis space,” said Asaf Zviran, CEO and Co-Founder at C2i Genomics.