New data from Daiichi Sankyo’s patritumab deruxtecan (HER3-DXd) from two early trials in patients with previously treated EGFR-mutated metastatic non-small cell lung cancer (NSCLC) (#PS1-2) or HER3 expressing metastatic breast cancer (#PS2-4) were presented during two Presidential Sessions at the Japanese Society of Medical Oncology Annual Meeting.

Patritumab deruxtecan is a specifically engineered potential first-in-class HER3 directed antibody drug conjugate (ADC) designed using Daiichi Sankyo’s proprietary DXd ADC technology.

Lung and breast cancer are the first and fifth leading causes of cancer-related deaths worldwide, accounting for approximately 1.8 million and 685,000 deaths in 2020, respectively.

“Most patients with lung or breast cancer involved in these two early-stage trials were heavily pre-treated, underscoring the need for new and innovative treatment options to help improve outcomes,” said Mark Rutstein, MD, Global Head, Oncology Clinical Development, Daiichi Sankyo. “These results further add to the growing body of evidence that targeting HER3 with patritumab deruxtecan may be a promising therapeutic option for a wide array of patients across several subtypes of metastatic lung and breast cancer.”

“Patritumab deruxtecan demonstrated a median overall survival of more than 15 months, which is particularly impressive in heavily pretreated patients with locally advanced or metastatic EGFR-mutated non-small cell lung cancer,” said Hidetoshi Hayashi, MD, PhD, Associate Professor, Department of Medical Oncology at Kindai University, Osaka, Japan. “Further clinical evaluation of patritumab deruxtecan in EGFR-mutated NSCLC is underway.”