Biopharmaceutical laboratories can now benefit from high-quality mass information delivered by Orbitrap technology for molecule attribute monitoring in development and quality control (QC). This offering is a part of a multi-attribute method (MAM) workflow that offers reduced downtime and maintenance and provides seamless method transfers from development to QC.

The Thermo Scientific Orbitrap Exploris MX mass detector offers high-resolution accurate mass (HRAM) data for intact analysis of monoclonal antibodies (mAbs), oligonucleotide mass determination and peptide mapping, making it ideal for biopharma process confirmation. The offering enables accelerated drug characterization processes in QC and productivity improvements by fully integrating the Orbitrap Exploris MX into the MAM 2.0 workflow, thereby replacing multiple assays into one information-rich mass spectrometric assay. Furthermore, the hardware and software transition from using the Thermo Scientific Orbitrap Exploris 240 mass spectrometer in the development stage to using the Orbitrap Exploris MX mass detector in QC stage is made seamless by the compliance-ready Thermo Scientific Chromeleon chromatography data system (CDS) software.

"The Orbitrap Exploris MX mass detector is integrated with our MAM 2.0 offering to help streamline workflows, provide our customers with confidence in their results, and simplify workflow operation," said Iain Mylchreest, vice president, research and development, analytical instruments, Thermo Fisher Scientific. "We strive to exceed our customers' needs by providing built-for-purpose, user-friendly solutions that deliver high-quality and reliable data."