By: IPP Bureau
Last updated : September 24, 2025 8:22 pm
The new Houston site, Lilly's eighth U.S. manufacturing facility announced since 2020, will focus on domestic production of small molecule synthetic medicines
Eli Lilly and Company plans to build a new $6.5 billion manufacturing facility at Generation Park in Houston, Texas.
This planned next-generation synthetic medicine active pharmaceutical product (API) facility, the second of four new U.S. sites Lilly will announce this year, will focus on manufacturing the company's pipeline of small molecule medicines across therapeutic areas, including cardiometabolic health, oncology, immunology and neuroscience. It is expected to be operational within five years.
Lilly will bring 615 new high-wage jobs to the Greater Houston area, including highly skilled engineers, scientists, operations personnel, and lab technicians. The company also expects to generate 4,000 construction jobs as the site is being built and brought online.
Importantly, the site will be among those that will manufacture orforglipron, Lilly's first oral, small molecule GLP-1 receptor agonist, which the company expects to submit to global regulatory agencies for obesity by the end of this year.
"Our new Houston site will enhance Lilly's ability to manufacture orforglipron at scale and, if approved, help fulfill the medicine's potential as a metabolic health treatment for tens of millions of people worldwide who prefer the ease of a pill that can be taken without food and water restrictions," said David A. Ricks, Lilly chair and CEO. "This significant U.S. investment and onshoring of our API production capabilities will ensure faster, more secure access to orforglipron and to other life-changing medicines of the future."
"Texas is the economic engine of America because we foster innovation and empower businesses to succeed," said Governor Greg Abbott. "Texas is proud to welcome Lilly to Houston as they make one of the largest pharmaceutical manufacturing investments in our nation's history and provide good, high-paying jobs to hardworking Texans. With our highly skilled workforce, low taxes, and world-class, business-friendly climate, Texas is the best place for companies like Lilly to grow. This $6.5 billion facility will not only bolster Houston's economy, it will boost our life sciences sector and help cement Texas as a global leader in health care innovation."
Lilly plans to use state-of-the-art technologies including machine learning, AI, digitally integrated systems and advanced data analytics to drive right-first-time execution. Digital automation will be embedded throughout the site to streamline operations and ensure a reliable supply of safe, high-quality medicines. To achieve this, the company will collaborate with local universities and invest in educational initiatives across Texas to build a strong pipeline of talent.
"With this new chemical synthesis facility, we are expanding our vital advanced pharmaceutical capabilities in the U.S. and setting a new global benchmark for innovation and technical leadership in our industry," said Edgardo Hernandez, executive vice president and president of Lilly Manufacturing Operations. "Additionally, we are committed to sustainability, being a responsible steward of natural resources, and strengthening the communities where our employees live and work."