By: IPP Bureau
Last updated : March 16, 2022 1:55 pm
Career achievement for contributions in Physiologically based pharmacokinetic (PBPK) and biologically based does response (BBDR) modelling tools
Jeffrey W. Fisher, PhD, has been awarded the 2022 SOT Arnold J. Lehman Award for his exceptional, consistent, career-long body of work on physiologically based pharmacokinetic (PBPK) and the biologically based dose-response (BBDR) modelling tools to improve risk assessment.
The Arnold J. Lehman award recognizes a SOT member who made a major contribution to risk assessment and/or the regulation of chemical agents, including pharmaceuticals.
Dr. Fisher’s work influenced many high-visibility risk-based regulatory decisions by both the US Environmental Protection Agency (EPA) and the US Food and Drug Administration (US FDA). He has provided training by coursework, mentoring, and publications on good practices for the use of PBPK and BBDR models in contemporary risk assessments.
A few of Dr. Fisher’s accomplishments include:
Publications on the pharmacokinetics of trichloroethylene (TCE) in rats during gestation and lactation that had a pivotal impact on the acceptance of PBPK modelling in studies of early life and served as the impetus for the subsequent widespread application of PBPK modelling of developmental pharmacokinetics.
Research that improved risk assessments for many chemicals. Modelling the effects of perchlorate on the thyroid of a pregnant woman, which became the basis for the US EPA BBDR model of perchlorate in their recent assessment of safe drinking water concentrations of the chemical and assisted US FDA regulatory scientists in the pharmacokinetic analyses of a per- and polyfluoroalkyl substance (PFAS), 6:2 FTOH, in animals and humans.
ScitoVation CEO, Dr. Jean Orelien, is proud of Dr. Fisher’s achievements and is pleased to have him as part of the team, "It’s an honour to work with Jeff and we value his many contributions to ScitoVation. This award is a testament to our commitment as a company to continue to be a scientific leader in advancing the methods and technology for assessing the safety and efficacy of chemical compounds."
Dr. Fisher humbly attributes his award to those who supported him, "I am honoured and humbled to receive the Arnold J. Lehman SOT award. I thank all the people who helped me during my career. Without them my accomplishments would not be possible."
An SOT member since 1990, Dr. Fisher served twice as President of the Biological Modeling Specialty Section. The award will be presented live at the 61ST Annual Meeting of Society of Toxicology (TOX) in San Diego, CA on March 27th at 5:15pm.