The discontinuation decision is only on the basis of commercial reasons and is not due to efficacy or safety reasons
The drug will target specific genetic mutations prevalent in certain types of cancers
Olaparib is indicated primarily for certain forms of ovarian, breast, pancreatic, and prostate cancer
First and only PARP inhibitor to improve invasive disease-free survival, the primary endpoint, and overall survival, a key secondary endpoint of the OlympiA trial, in these patients
Lynparza is the first and only approved PARPi targeting BRCA-mutated HER2-negative high-risk early breast cancer
First PARP inhibitor to demonstrate clinical benefit in radiographic progression-free survival in combination with a new hormonal agent with or without homologous recombination repair gene mutations
First and only PARP inhibitor to improve overall survival in early breast cancer
Imfinzi also recommended for patients with mismatch repair deficient disease
Approval based on DUO-E trial results, which showed Imfinzi reduced the risk of disease progression or death by 58% vs. chemotherapy
The receipt of this permission paves way for the launch of Olaparib film coated tablets in India
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