Interim results from the first co-administration descriptive study of Sanofi’s Fluzone High-Dose Quadrivalent vaccine with Moderna’s Covid-19 mRNA investigational booster dose show that the administration of the vaccines at the same visit had similar immunogenicity responses and similar safety and tolerability profile compared to each vaccine administered individually.

Fluzone High-Dose Quadrivalent is a high-dose quadrivalent influenza vaccine, indicated for adults aged 65 and older in the United States and Canada. It is also licensed under the brand name Efluelda in Europe where it is indicated for adults aged 60 and older. Fluzone High-Dose is the only influenza vaccine that has demonstrated reductions in influenza-related complications such as hospitalisations due to cardiovascular events and pneumonia, over 10 consecutive seasons in more than 34 million people aged 65 and older.

According to Dr Michael Greenberg, North America Medical Head for Vaccines at Sanofi. “This is the first study to provide supportive evidence for vaccinating against influenza at the same time as a COVID-19 mRNA booster in seniors. These positive results could facilitate the implementation of Northern Hemisphere influenza and COVID-19 booster vaccination campaigns, especially in this high-risk population.”

These encouraging results reinforce existing co-administration recommendations across the world. Concomitant use of Covid-19 vaccines and influenza vaccines is currently permissible in several countries, including the US, France, the UK and Germany.