Innovent Biologics and Sanegene Bio USA announce that they have entered into a collaboration agreement to co-develop SGB-3908, an siRNA drug candidate targeting angiotensinogen (AGT) for the treatment of hypertension. Innovent also obtains an exclusive option to license in the future development, manufacturing and commercialization rights of SGB-3908.

SGB-3908 is an IND-enabling stage siRNA drug developed based on SanegeneBio's proprietary LEAD™ (Ligand and Enhancer Assisted Delivery) platform. Under the terms of the agreement, both parties will be jointly responsible for the development of SGB-3908 to certain stage.

Innovent will receive an exclusive option to pay different option exercise fees to obtain the exclusive development, manufacturing, and commercialization license of SGB-3908 in different areas worldwide. After Innovent exercises its option, SanegeneBio will be eligible to receive subsequent milestone payments, as well as tiered royalties based on net sales.

Both parties will leverage their respective strengths, combining the cutting-edge RNA technology strength of SanegeneBio, and Innovent's rich clinical development experience and established commercialization capability to accelerate the development and ensure the commercial success of this innovative siRNA drug candidate so that it can benefit more hypertension patients as early as possible.