Evonik now offers cQrex KC, a performance-boosting peptide for cell culture media used in the manufacture of biological drugs. The new peptide enables cell culture process developers and media formulators in the biopharmaceutical industry to optimize cystine supply and increase cell culture productivity.

cQrex KC is the latest addition to Evonik’s toolbox of cQrex cell culture ingredients designed to increase efficiency and productivity in cell culture processes used to produce monoclonal antibodies, vaccines, viral vectors and cell therapies. The market for biological drugs – greater than €250 billion in 2022 - continues to grow, with several thousand products in the pipeline.

“We are excited about the opportunities cQrex KC offers to our customers. By enabling increased flexibility in media formulation and bioprocess design, we are helping more efficient production of biopharmaceuticals,” said Martin Schilling, director of Cell Culture Ingredients at Evonik’s Health Care business.

Adding cQre KC to Evonik’s market-leading cQrex portfolio and accompanying application services, strengthens the company’s offerings of System Solutions. Nutrition & Care, the life sciences division at Evonik that is home to the Evonik Health Care business, aims to increase its share of System Solutions from 20 percent to more than 50 percent by 2030. System Solutions are defined as multicomponent systems tailored to a specific customer need.

L-cystine is a key amino acid in cell culture. Sufficient supply is critical to support cell growth and production of biopharmaceuticals. However, L-cystine is hardly soluble in cell culture media at neutral pH, so it is difficult to supply enough of this amino acid to cells cultured in modern industrial processes that rely on chemically defined media.

cQrex KC is a highly pure and soluble peptide designed to address the challenge of L-cystine supply in cell culture. It allows the formulation of concentrated and pH-neutral feed and perfusion media, as well as basal media, therefore intensifying and simplifying complex production processes. By increasing the cell proliferation, viability and cell-specific productivity, cQrex KC also contributes to higher antibody titers and increased overall productivity of biological drugs.