Lonza has reported sales of CHF 3.1 billion and sales growth of 3.2% AER3 (5.6%1 CER), corresponding to around 10% CER underlying sales growth. CHF 922 million CORE EBITDA resulted in a margin of 30% in H1 2023. Sales growth from sustained demand for commercial CDMO services more than offset post-pandemic mRNA sales, lower growth in early-stage services driven by biotech funding constraints, and a decline in demand for nutraceutical capsules. 

Solid underlying growth in the Biologics division was driven by the Bioconjugates, Mammalian and Microbial business units. Strong performance in Small Molecules was supported by high asset utilization and a focus on more complex and high value offerings.

Business highlights in the First Half included the acquisition of Synaffix and its leading clinical-stage technology platform focusing on linker technology for antibody-drug conjugates (ADCs). Lonza also entered an agreement with Vertex to build a dedicated manufacturing facility for type 1 diabetes cell therapies at its Portsmouth (US) site.

Lonza updated its guidance to reflect current market dynamics impacting demand for early-stage services and nutraceutical capsules driving underutilization. Outlook 2023 was updated from high single-digit to mid-to-high single-digit CER sales growth, and from 30-31% to 28-29% CORE EBITDA margin. Mid-Term Sales Guidance was confirmed, with a margin range updated from 33-35% to 31-33%.

Pierre-Alain Ruffieux, CEO, Lonza, commented: “Our CDMO business is underpinned by partnership models and long-term contracts for commercial supply that provide a solid foundation for long-term stability and success. We continue to see strong underlying growth momentum, despite lower growth in demand for early-stage services and nutraceutical capsules.

“As we look towards the Second Half, ramp-up of new commercial assets in Biologics will support sales growth. More widely, we will also continue to focus on delivering our growth projects and driving continuous improvement across our global network.”

As part of its emission reduction strategy, Lonza has submitted a letter of commitment to the Science-Based Targets initiative (SBTi) with plans to reduce absolute scope 1 and 24 greenhouse gas emissions by more than 40% by the end of 2030 (from a 2021 base). Lonza also signed a ten-year virtual power purchase agreement with renewable energy company IGNIS to generate more than 300 GWh of solar power annually, matching the company’s electricity needs across Switzerland and the European Union. Together, these agreements underline Lonza’s long-term commitment to sustainable business practice.

Group Outlook 2023 update: mid-to-high single-digit CER sales growth and 28 to 29% CORE EBITDA margin, reflecting slower growth than expected in early-stage services and continued weak demand in the nutraceutical capsules market driving underutilization