CEPI funds consortium led by CPI to advance Caltech’s new all-in-one coronavirus vaccine
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CEPI funds consortium led by CPI to advance Caltech’s new all-in-one coronavirus vaccine

Up to $30m funding will be provided to advance an innovative vaccine technology that could protect against current and future SARS-CoV-2 variants and other SARS-like Betacoronaviruses.

  • By IPP Bureau | July 15, 2022

The Coalition for Epidemic Preparedness Innovations (CEPI) has partnered with a consortium of research and technological institutions to develop a novel vaccine to provide protection against COVID-19 caused by current and future SARS-CoV-2 variants, as well as to protect against other SARS-like Betacoronaviruses.

The project will be led in manufacturing efforts by UK-based deep tech innovation organisation CPI to advance the novel vaccine developed at Caltech and The University of Oxford, and manufactured using microbes engineered by industrial biotechnology leader, Ingenza Ltd.

CEPI will provide up to US $30 million to support the development of the vaccine through Phase I trials, including preclinical work, with the aim to establish first-in-human clinical proof of concept for the vaccine. The funding will also support the design of the vaccine and regulatory activities.

Recognising the risk of future coronavirus threats, CEPI has established itself as the global leader in funding all-in-one coronavirus vaccine research. This is the eleventh award to be made as part of CEPI’s US $200 million programme supporting projects that could provide broad protection against SARS-CoV-2 variants and other Betacoronaviruses. CEPI also today announced another broadly protective coronavirus vaccine partnership with Codiak Biosciences. The programme is a central part of CEPI’s innovative US $3.5 billion pandemic preparedness plan that seeks to reduce, or even eliminate, the threat of future pandemics.

Dr Richard Hatchett, CEO of CEPI, said: “There have already been three serious coronavirus epidemics or pandemics in the twenty-first century – and COVID-19 continues to have a devastating impact on the world’s health, society, and economy.

“The creation of vaccines that could provide broad protection against emerging COVID-19 variants and future coronavirus threats would not only help mitigate the damaging effects of another COVID-19-like pandemic, it could also help reduce the time taken and funding spent continually updating vaccine formulations.

“That’s why we are delighted to today partner with this CPI-led innovation consortium to build on Wellcome Leap’s initial investment in Caltech’s technology and further advance this pioneering mosaic nanoparticle vaccine approach that, if successful, could work towards consigning the threat posed by coronaviruses to the history books.”

Kris Wadrop, CPI General Manager and the Project Lead, said: “CPI has been working together with these partners since mid-2020 to develop this type of vaccine to ensure it can be manufactured in the quantities and price range required to have a real impact everywhere. Confirmation of this funding is a testament to the team’s diligence and tenacity to highlight the potential offered by an RBD-nanoparticle vaccine.” 

“The strength assembled in this world-class team is providing excellence in research and science with pragmatism in production technology and market knowledge. We are really excited to be working with our partners and leading this consortium from the Tees Valley, in Northeast England.”

Dr. Pamela Bjorkman, the Project Lead and David Baltimore Professor of Biology and Biological Engineering and Merkin Institute Professor at Caltech, said: “I am grateful for support from Caltech’s Merkin Institute for Translational Research that allowed my lab to start the mosaic-8 project shortly after the COVID-19 pandemic began, to Wellcome Leap for their support of preclinical studies in non-human primates, and to the Bill and Melinda Gates Foundation for on-going support. We are now thrilled to be working with CEPI and our colleagues at Oxford, Ingenza, and CPI to move this vaccine candidate into the clinic. We are very encouraged by preclinical results assessing the mosaic RBD nanoparticle approach, which has demonstrated advantages over current vaccines and traditional single RBD nanoparticle vaccine candidates. Our consortium has already combined its diverse skill sets to implement new ideas and scientific advances, and we look forward to continuing to work with our wonderful collaborators.”

Prof. Alain Townsend, Professor of Molecular Immunology at the MRC Human Immunology Unit, University of Oxford, said: “The evolution of this consortium is an example of collaborative science at its best. We had been deeply impressed by the power of the protein “glue” for sticking proteins together, and using this technology developed at University of Oxford, my lab made a prototype nanoparticle SARS-CoV-2 vaccine that induced highly potent responses in preclinical studies. Through connections made by Ian Wilkinson (Absolute Antibody), we joined with colleagues at Ingenza and CPI who succeeded in producing a fully functional vaccine produced in microbes, reducing the cost of production. We have been collaborating with Prof. Pamela Bjorkman and the Caltech team, who had independently developed the brilliant concept of the mosaic version of the vaccine and are excited to continue working with this world-class consortium.”

Dr. Jack Tan, Senior Postdoctoral Scientist at the MRC Weatherall Institute of Molecular Medicine, University of Oxford, added: “We are excited to be part of the consortium to support the pre-clinical development and move this vaccine candidate into the clinic with the expert guidance of Dr. Parvinder Aley and Prof. Sir Andrew Pollard of the Oxford Vaccine Group. We are delighted to be working with CEPI to further this nanoparticle technology with the goal of producing efficacious, low-cost, infrastructure-independent vaccine that will be accessible to low- and middle-income countries.”

Ian Fotheringham, the Managing Director of Ingenza, said: “It has been a pleasure to work within this phenomenal consortium. This program is a validation of Ingenza’s consistent and ongoing investment in efficient and sustainable biomanufacturing technologies that will accelerate innovative biologics and vaccine candidates to worldwide deployment. Our commitment to enhancing human health and a sustainable and equitable global environment fundamentally underpins our engagement with these consortium partners to deliver this next-generation vaccine.”

Initial development and validation of the prototype mosaic-8 vaccine approach was supported by Wellcome Leap and Caltech’s Merkin Institute for Translational Research.

Wellcome Leap provided the pivotal support needed to achieve the current results; and, importantly, to maintain the scientific momentum catalysed by Merkin’s earlier funding. Acceleration of the preclinical study allowed it to be completed in time to secure funding from CEPI’s broadly protective Betacoronavirus vaccine call for the Phase I clinical trials announced today. Taken together, these efforts have the potential to condense the path to full-scale production by three to four years.

Regina E. Dugan, CEO of Wellcome Leap, said: “This early transition success demonstrates the value of global partnerships working collaboratively and with the urgency needed to address future pandemic risks.” 

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