Advanced Enzyme Technologies which introduced its systemic enzyme and probiotic supplements—ImmunoSEB and ProbioSEB CSC3 to treat fatigue symptoms that develop post Covid-19 recovery has announced that its products have passed the randomised controlled clinical trials for efficacy.

They claim to have plugged the gap that existed as patients who recovered from Covid-19 experience muscle fatigue and cognitive disturbances and there is no specific treatment. The company’s supplements bridge the gap.  

To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from Covid-19 induced fatigue, a randomized, multi-centric, double-blind and placebo-controlled trial was conducted in 200 patients suffering from post-Covid-19 fatigue symptoms.

The test arm (100 patients) received the oral supplements for 14-days and the control arm (100 patients) received placebo, informed Dr. Abhijit K. Rathi, Principal Scientist, AETL.

The randomized clinical trial was conducted on 200 patients that did not have an active SARS-CoV-2 infection, as determined by a negative Covid-19 test, with a complaint of post-Covid-19 fatigue. Patients were required to have a positive Covid-19 test at any time in the past. The trial was conducted across three centres in India-Swasthya Hospital, Bhopal; Samvedna Hospital, Varanasi; and Chirayu Medical College & Hospital, Bhopal by Investigators for 14-days, informed Dr Rathi.

According to the clinical research paper published by the Switzerland-based "Medicines" Journal on August 30, 2021, the treatment efficacy was compared using the Chalder Fatigue Scale (CFQ-11) for 14-days. Interestingly, the supplemental treatment resulted in the resolution of fatigue in a greater percentage of patients during the test as against the control arm (91% vs. 15%) during the 14-day trial. Patients in the test arm category showed a significantly greater reduction in the overall physical and mental fatigue scores as against patients in the control arm segment. The supplements were well tolerated with no adverse events reported. This clinical study demonstrated that the 14-day supplementation of ImmunoSEB and ProbioSEB CSC3 resolved post-Covid-19 fatigue symptoms and improved patients' functional status and quality of life, informed Dr. Rathi.

The products are currently available globally on the leading e-commerce marketplace - Amazon. In a move to further shore up its direct-to-customer (D2C) omnichannel retailing business, AETL has unveiled its online store - 'Advanced Enzymes e-Direct Store' in September 2021 to help customers choose from a wide range of health support products