AIG Hospitals along with researchers from the Asian Healthcare Foundation conducted a pilot study to determine the safety profile of mixing Covishield and Covaxin along with checking the antibody response. A total of 330 healthy volunteers who were not vaccinated and had no history of Covid-19 infection were selected and screened for SARS-CoV-2 antibodies for the study. Out of these 330, 44 (13%) participants were found to be seronegative, i.e., they didn’t have Covid-related antibodies.

The most important finding of the study was that the Spike-protein neutralizing antibodies found in the mixed vaccine groups were significantly higher than the same-vaccine groups.

 “One of the incidental findings of the study is the seropositivity among our population. 87% of participants who didn’t get vaccinated and never tested positive for Covid-19 had Covid-19 related antibodies. This means our population might have developed significant antibodies against Covid-19 because of the huge Delta wave that we endured,” said Dr. D Nageshwar Reddy, Chairman, AIG Hospitals.

Dr. Reddy who is also among the researchers involved in the study said “Spike-protein neutralizing antibodies are the ones which kill the virus and reduce the overall infectivity. We found that when the first and second dose is of different vaccines, the Spike-protein antibody response is four times higher compared to two-dose of the same vaccine.” “This is particularly important when considering the third booster dose. The concept of a booster is to elicit a robust antibody response and help in killing the virus. Mixed doses can certainly boost these Spike protein neutralizing antibodies and will enhance the vaccines’ effectiveness even against the Omicron variant,” Dr. Reddy further added.

The study results show that mixing of Covid-19 vaccines (Covishield and Covaxin) provide a higher antibody response and is safe as well.

The 44 participants were divided into two four groups.

Group 1: First Dose Covishield + Second Dose of Covishield

 Group 2: First Dose of Covaxin + Second Dose of Covaxin

Group 1 and 2 were the homologous vaccine groups in which the same vaccine have been given and relevant antibody titers were checked.

Group 3: First Dose of Covishield + Second Dose of Covaxin

Group 4: First Dose of Covaxin + Second Dose of Covishield

Group 3 and 4 were the heterogeneous vaccine groups in which different vaccines were given and antibody titers were checked.

All these 44 participants were followed for 60 days to see if there’re any adverse effects. The study conclusively showed that mixing of vaccines are safe as none of the participants developed any adverse effect.

Furthermore, AIG Hospitals has shared the data from the study with the ICMR (Indian Council for Medical Research) to be considered as a reference study while deciding on the “Prevention” doses starting January