Parse Biosciences, a leader in accessible and scalable single-cell sequencing, has announced a major upgrade to its data analysis platform, Trailmaker, with a fully integrated immune repertoire and whole transcriptome workflow.  

The new functionality complements Parse’s existing Evercode immune products, delivering a complete end-to-end solution for immunologists. 

Until now, researchers have struggled to link immune repertoire data with single-cell transcriptome insights, often piecing together fragmented tools, custom code, or inconsistent visualizations. Trailmaker’s new workflow solves this problem, providing an all-in-one platform that unites repertoire and transcriptional information. 

The upgrade gives scientists a comprehensive view of clonal structure, diversity, and antigen-driven signatures. Users can now visualize clonotypes and cell types on an integrated UMAP, quickly spot dominant clones with frequency and honeycomb plots, and detect conserved patterns through motif analysis.  

By connecting repertoire data with full transcriptome expression, Trailmaker enables researchers to map clonotypes to their transcriptional states, uncover clonotype-specific gene programs, and run targeted differential expression for deeper biological insights. 

“Our goal has always been to remove barriers for researchers,“ said Charlie Roco, Co-founder and Chief Technology Officer at Parse. “By making immune profiling intuitive and more fully integrated, we’re empowering immunologists to spend less time wrangling the data and more time assigning biological significance.”