Regulatory authorities of China have approved the mixing of domestic inactivated vaccines against Covid-19 (in particular, Sinovac and Sinopharm) and use of a different vaccine, including adenoviral-based, as booster shot.  This opens doors for Russian Sputnik V vaccine to be administered as a booster.

Vaccines produced by Chinese companies (Sinovac and Sinopharm) are widely used with over 4.7 billion doses supplied in China and globally. While China’s State Council has authorized mix & match boosting only with domestic vaccines, the Russian one-shot Sputnik Light vaccine (the first component of Sputnik V) can become a solution for boosting those initially vaccinated with Chinese vaccines in other countries around the world.

Sputnik Light has already shown strong results used as a booster in mix & match trials, including for inactivated vaccines. For example, the study conducted in Argentina on Sputnik Light combination with other vaccines has shown that antibody and T-cells response elicited by Sputnik Light as a booster to inactivated Sinopharm vaccine is 10x higher vs two shots of Sinopharm. The study also has demonstrated that each “vaccine cocktail” combination with Sputnik Light with other vaccines like Moderna, AstraZeneca and Cansino had provided a higher antibody titer on the 14th day after administering a second dose when compared to original homologous (same vaccine as first and second dose) regimens of each of the vaccines. Using Sputnik Light in combinations with all other vaccines showed high safety profile with no serious adverse events following the vaccination in any combinations.

The highest safety and efficacy of Sputnik V and Sputnik Light was demonstrated in more than 30 studies and real-world data publications from more than 10 countries.

Sputnik V and Sputnik Light can be stored in a conventional refrigerator at +2 +8ºC for 6 months, making them available globally, including in remote territories, without any need to invest in additional cold-chain infrastructure.